At an Antarctica research site, the discovery of an alien craft leads to a confrontation between graduate student Kate Lloyd and scientist Dr. Sander Halvorson.

Twins journey to the Middle East to discover their family history and fulfill their mother's last wishes.

At CERN, Father Silvano and Dr. Vittoria Vetra create three canisters of antimatter. Silvano is murdered, and one of the canisters is stolen. The Roman Catholic Church mourn the sudden death of Pope Pius XVI, and prepare for the papal conclave to elect his successor in Vatican City. Father Patrick McKenna, the Camerlengo of the Holy Roman Church, takes control of the Vatican. Four of the “preferiti”, the favoured candidates to be Pope, are kidnapped by a man claiming to represent the Illuminati. He sends the Vatican a warning, claiming he will murder each of the cardinals from 8pm to midnight, where the stolen antimatter will explode and destroy the city, hidden somewhere within.